Talk:Ras GTPase

Molecular Biology: Genetics / MCB / Cell Signaling

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RTK/Ras/MAPK signaling[edit]

I'm not familiar enough with it but could somebody please introduce more in the context of RTK/Ras/MAPK signaling? -- xy (talk) 09:47, 15 October 2008 (UTC)[reply]

changes[edit]

I have changed the Constitutively active Ras entry from the wrong: Constitutively active Ras (RasD) contains a mutation that blocks the functional binding of GAP and "locks" Ras in the active GTP-bound state.

To what you see now. --Adamshutes 00:00, 24 Oct 2004 (UTC)adamshutes

I changed the shorthand "Pi" to "inorganic phosphate" because it's less confusing.

Confuseddave 18:01, 2 January 2006 (UTC)[reply]

Some links to sort through[edit]

I'm putting some links here fairly indiscriminately until I decide (or someone else does) which if any are worth adding to the article itself.

Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate, Pablo Rodriguez-Viciana et al. [1]

Transformation Potential of Ras Isoforms Correlates with Activation of Phosphatidylinositol 3-Kinase but Not ERK, Weiquan Li et al. [2]

The Cell, Alberts et al. [3]

Cancer Medicine 6 [4]

The Ras/Raf/MEK/Extracellular Signal-Regulated Kinase Pathway Induces Autocrine-Paracrine Growth Inhibition via the Leukemia Inhibitory Factor/JAK/STAT Pathway, Jong-In Park et al.[5]

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. W Kolch abstract [6] pdf[7]

any history of the name?

Acronym[edit]

The article doesn't explain what R.A.S. actually stands for ? XApple (talk) 13:58, 17 May 2010 (UTC)[reply]

Yes it does. (RA)t (S)arcoma. Originally cloned from a rat sarcoma, or neoplasm of mesenchymal origin. —Preceding unsigned comment added by 98.14.206.81 (talk) 00:43, 29 June 2010 (UTC)[reply]

== Too technical == isabella c

I was looking for something to explain the Ras oncogene to a college freshman taking an introductory biology course. That's certainly part of the target audience for this article. I don't think it meets that test.

The problems start with the introduction. WP:NOTPAPER: "Introductory language in the lead and initial sections of the article should be written in plain terms and concepts that can be understood by any literate reader of Wikipedia without any knowledge in the given field before advancing to more detailed explanations of the topic. While wikilinks should be provided for advanced terms and concepts in that field, articles should be written on the assumption that the reader will not or cannot follow these links, instead attempting to infer their meaning from the text."

The introduction starts with terms like "GTPases" and "signal transduction", which most people wouldn't be familiar with at least until after they had finished a biology course. You can't define terms with other terms that the reader doesn't understand.

Campbell's biology is an example of how it is possible to define it in terms that a high school student can understand:

"ras gene. This gene codes for Ras protein, a G protein that relays a growth signal from a growth factor receptor on the plasma membrane to a cascade of protein kinases that ultimately results in the stimulation of the cell cycle. Many ras oncogenes have a point mutation that leads to a hyperactive version of the Ras protein that can lead to excessive cell division."^[1] --Nbauman (talk) 19:20, 25 November 2011 (UTC)[reply]

I've had a go at plain-Englishing the opening paragraphs - let me know what you think! HenryScow (talk) 13:46, 30 November 2011 (UTC)[reply]

It looks like this problem has been addressed, at least for the lead. Tag removed. MartinPoulter (talk) 15:24, 14 May 2012 (UTC)[reply]

References

^ Reece, Jane; Campbell, Neil (2002). Biology. San Francisco: Benjamin Cummings. ISBN 0-8053-6624-5.{{cite book}}: CS1 maint: multiple names: authors list (link)

Clinical Studies[edit]

Why is Reolysin on here? That therapy is completely unrelated to alterations in RAS. This is just an attempt by the reolysin people to hype their product. — Preceding unsigned comment added by 155.52.122.136 (talk) 20:58, 18 September 2013 (UTC)[reply]

[Campbell-1] Reece, Jane; Campbell, Neil (2002). Biology. San Francisco: Benjamin Cummings. ISBN 0-8053-6624-5.{{cite book}}: CS1 maint: multiple names: authors list (link)

[1]