Talk:Alpha-1 antitrypsin deficiency

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Amyloid[edit]

Alpha 1-antitrypsin deficiency is not due to amyloid (as stated in this article). The proteins deposited within liver Cells do not have the characteristics of amyloid.

Correct. It is, however, accumulated protein. I'll change the article to fit this. PS Get a username and put your knowledge to use!! We'd love to have you! JFW | T@lk 19:14, 24 May 2004 (UTC)

allergys[edit]

do allergys make alpha1 worse since the allergen has to get destroyed? —The preceding unsigned comment was added by 75.146.18.113 (talk) 01:33, August 24, 2007 (UTC)

listings[edit]

Why does it list both COPD and emphysema, when emphysema is a subgroup of COPD?

Incorrect information in this article[edit]

The information in this article (Alpha 1-Antitrypsin Deficiency) contains significant misinformation. The section towards the end includes the medical recommendation that individuals with this condition take paracetamol (aka acetaminophen or Tylenol) at the least provocation because it will reduce the accumulation of protein within the liver. There is absolutely no evidence to support this and, in fact, there is growing concern that even recommended doses of acetaminophen or paracetamol can be toxic to the liver. I have edited this section of the article on several occasions and each time, within hours of the edit a program or person named Smackbot re-edits it back to the original version. I can only assume this is a misinformed patient or, worse, a manufacturer of paracetamol behind this potentially dangerous misinformation.

Added comment: I am pleased to see that this misleading information has finally been removed from this article. Thank you.

Robert Sandhaus, MD, PhD Clinical Director, Alpha-1 Foundation Professor of Medicine National Jewish Health —Preceding unsigned comment added by Ssandhaus (talkcontribs) 18:00, 13 June 2009 (UTC)

Dr Sandhaus's Excellent New England Journal Review Article[edit]

Dr Sandhaus recently published an excellent review article in the New England Journal of Medicine on Alpha 1-Antitrypsin Deficiency that should be incorporated into the article. Let's be diligent about citing appropriate sources and deleting unreferenced statements. If certain users continue to re-insert unreferenced claims, perhaps administrative action can be taken.

Dr Sandhaus's article: http://content.nejm.org/cgi/content/full/360/26/2749 Wawot1 (talk) 03:00, 9 July 2009 (UTC)

New article about evidence of a1 treatment should be included: http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(15)60860-1/abstract MichelleLily14 (talk) 06:55, 28 July 2015 (UTC)

Michael Jackson was said to have Alpha-1 antitrypsin deficiency[edit]

=[edit]

One of my sources suggested that he might already have had a genetic condition I had never previously come across, called Alpha-1 antitrypsin deficiency – the lack of a protein that can help protect the lungs.

Although up to 100,000 Americans are severely affected by it, it is an under-recognised condition. Michael was receiving regular injections of Alpha-1 antitrypsin derived from human plasma. The treatment is said to be remarkably effective and can enable the sufferer to lead a normal life.

But the disease can cause respiratory problems and, in severe cases, emphysema. Could this be why Jackson had for years been wearing a surgical mask in public, to protect his lungs from the ravages of the disease? Or why, from time to time, he resorted to a wheelchair? When I returned to my source inside the Jackson camp for confirmation, he said: ‘Yeah, that’s what he’s got. He’s in bad shape. They’re worried that he might need a lung transplant but he may be too weak.

- Ian Halperin, 28th June 2009

http://www.dailymail.co.uk/news/article-1196009/Im-better-dead-Im-How-Michael-Jackson-predicted-death-months-ago.html

==[edit]

Tabloid (Halperin is a filthy tabloid journalist anyway - all his "insider sources" are in his fantasy). Jackson's autopsy didn't confirm this. Neither any of his doctors or friends confirmed this (while they confirmed that he had lupus and vitiligo, but nobody ever mentioned Alpha 1-antitrypsin except for Halperin who didn't even know the singer). Halperin first claimed this in December 2008 when Jackson's spokesperson immediately denied it. Back then Halperin also claimed that MJ needs a lung transplant and is in such a bad condition that he is unable to walk and even talk. Of course, this was all refuted, not only by Jackson's spokesperson but also by facts, such as Jackson's "This is it" rehearsal footage which doesn't show a man unable to walk and talk, let alone in desperate need of a lung transplant.

I suspect this is just a tabloid journalist looking up a condition in a medical dictionary and attaching it to a celebrity without foundation.

Here is an article refuting Halperin's claims: http://www.foxnews.com/story/0,2933,470985,00.html

Inheritance[edit]

Can we confirm the mechanism of inheritance. OHCM 7 says it is auto rec. Snellios (talk) 21:58, 21 July 2010 (UTC)

yep, i [citation needed] 'd it. it's technically dominant, but doesn't express fully unless both copies are present. can someone with absolutely cast-iron credentials please call this one?Andrewjlockley (talk) 14:50, 28 December 2010 (UTC)

Misspelled title? Change "Alpha 1-antitrypsin" to "Alpha-1 antitrypsin"?[edit]

Our current article generally spells it "Alpha-1 antitrypsin", with just one inconsistent appearance of "Alpha 1-antitrypsin" in the text, and two captions saying "Alpha-1-antitrypsin". Nevertheless, our current title is "Alpha 1-antitrypsin", which none of our references use. Should it be changed to "Alpha-1 antitrypsin"? —173.68.139.31 (talk) 23:31, 26 July 2019 (UTC)

Seems it was wrongly redirected some time ago - have put in a page move request. Thanks. Iztwoz (talk) 06:10, 27 July 2019 (UTC)
Appreciate the quick fix. Is it possible to do something similar for the misspelled Commons category, too, in the External Links section? —173.68.139.31 (talk) 03:54, 28 July 2019 (UTC)

Consensus guidelines[edit]

This has been published a while ago but we make no reference to it: doi:10.15326/jcopdf.3.3.2015.0182 JFW | T@lk 10:28, 9 August 2019 (UTC)

The authorship is entirely American, so the recommendations may not reflect practice in other countries. JFW | T@lk 10:28, 9 August 2019 (UTC)

Added on the occasion of the IFAA 2019 conference. JFW | T@lk 14:06, 9 August 2019 (UTC)

ERS monograph[edit]

https://www.ersbookshop.com/alpha-1-antitrypsin-deficiency-424-p.asp JFW | T@lk 11:17, 18 September 2019 (UTC)