Talk:Scopolamine

Crime - Vice Documentary

I'll leave this here for any editor if they want it. I've never had much luck editing Wikipedia directly, but some of the references I've added in talk have worked here and there..

References

Use by the CIA in Project MKULTRA

"To Dr. Isbell, it was just another experiment. "I have had seven pa�tients who have now been taking the drug for more than 42 days," he wrote in the middle of the test, which he called "the most amazing demonstration of drug tolerance I have ever seen." Isbell tried to "break through this tolerance" by giving triple and quadruple doses of LSD to the inmates. Filled with intense curiosity, Isbell tried out a wide variety of unproven drugs on his subjects. Just as soon as a new batch of scopolamine, rivea seeds, or bufontenine arrived from the CIA or NIMH, he would start testing. His relish for the task occa�sionally shone through the dull scientific reports. "I will write you a letter as soon as I can get the stuff into a man or two," he informed his Agency contact. No corresponding feeling shone through for the inmates, however. In his few recorded personal comments, he com�plained that his subjects tended to be afraid of the doctors and were not as open in describing their experiences as the experi�menters would have wished. Although Isbell made an effort to "break through the barriers" with the subjects, who were nearly all black drug addicts"

References

Incorrect labelling of enzyme in diagram, 'Biosynthesis in Plants' section

The difference between hyoscyamine and scopolamine is an epoxy (C-O-C) ring on the latter. The reaction to form this ring would, I suppose, be catalysed by an 'epoxidase' rather than a 'hydroxylase' enzyme. Indeed, in the text this enzyme is identified as 6beta-hydroxyhyoscyamine epoxidase. Yet, in this diagram, the enzyme is named as 'hyoscyamine 6beta-hydroxylase'. I think that this is an error in the diagram : I think that this final enzyme of the diagram is mislabelled on the diagram. I do not know how to change this. Please will somebody check and change this Boleslaw (talk) 11:51, 7 May 2024 (UTC)

How is it produced?

How is scopolamine produced for medical use? Is it derived from plants, or completely produced by chemical processes? Can someone add that to the article? Jimhoward72 (talk) 20:28, 19 May 2024 (UTC)